HiPhenolic and Semaglutide: OTC & Prescription Approach to Weight Management

Weight management is a complex challenge, often requiring a multifaceted approach.

At HDRX, we understand that successful weight loss and maintenance hinge on not just diet and exercise but also on how we can enhance and support the body’s natural mechanisms.

In our ongoing commitment to health and wellness, let’s explore two innovative medicines doctors have been prescribing for their weight management patients: HiPhenolic and Semaglutide.

HiPhenolic is available for purchase, call or contact us online to order for pickup or shipping.

HiPhenolic, a potent polyphenolic supplement.


Semaglutide, a prescription compounded medication.

Let’s explore the science behind why they’ve been gaining popularity.


HiPhenolic is a potent polyphenolic (rich in polyphenols) supplement blend designed for those aiming to support weight management, by increasing satiety (fullness) and decreasing appetite.

HiPhenolic’s unique formula combines Green Coffee Bean Extract, Magnesium, and Metabolaid® — a dynamic fusion of Hibiscus and Lemon Verbena Extracts.

Order HiPhenolic >>

The Science Behind Polyphenols: GLP-1 and AMPK

Polyphenols are found in over-the-counter product HiPhenolic.

Recent studies delved into the role of dietary polyphenols in promoting the secretion of GLP-1 (glucagon-like peptide-1). This hormone plays a crucial part in reduction in appetite and an improvement in metabolism, thereby assisting in weight control. 

Exploring other factors that may improve metabolic conditions, the energy-regulating enzyme AMP-activated protein kinase (AMPK) is being deemed a key player for managing weight. When activated, AMPK stimulates the breakdown of fats and the burning of fatty acids, pathways crucial for obesity. 

Polyphenols were observed to activate AMPK, further making it a valuable ally in the battle against unwanted weight gain.

HiPhenolic Weight Loss Supplement Michigan

Interestingly, GLP-1 is also the mechanism through which Semaglutide, a compounded medication commonly prescribed for weight loss, operates. 

Questions about HiPhenolic or Semaglutide?

HiPhenolic: Unleashing the Potential of Polyphenols

HiPhenolic is formulated based on the understanding that certain plant-based compounds can interact positively with the body’s metabolic processes. Hibiscus sabdariffa (Hibiscus Flower), Lippia citriodora (Lemon Verbena) extracts, which are a cornerstone of HiPhenolic, have been associated with positive health outcomes. Specifically, overweight participants who incorporated these polyphenols into their daily routine saw significant improvements in body weight, abdominal circumference, and body fat percentage.

HDRX: Your Partner in Advanced Weight Management Approaches

Our team at HDRX takes pride in being at the forefront of medicine and supplementation innovation, offering expert insight into products like HiPhenolic and Semaglutide that are grounded in scientific research. 

Embarking on a weight loss journey can be daunting, but with HDRX, you don’t have to do it alone. Whether you’re a patient looking for support in managing your weight or a healthcare provider seeking reliable resources for your patients, we’re here to help.

As the leading family compounding pharmacy in Michigan, HDRX is dedicated to assist in your journey toward better health. 


  • Herranz-López, M., Olivares-Vicente, M., Boix-Castejón, M. et al. Differential effects of a combination of Hibiscus sabdariffa and Lippia citriodora polyphenols in overweight/obese subjects: A randomized controlled trial. Sci Rep 9, 2999 (2019). https://doi.org/10.1038/s41598-019-39159-5
  • Domínguez Avila JA, Rodrigo García J, González Aguilar GA, de la Rosa LA. The Antidiabetic Mechanisms of Polyphenols Related to Increased Glucagon-Like Peptide-1 (GLP1) and Insulin Signaling. Molecules. 2017 May 30;22(6):903. doi: 10.3390/molecules22060903. PMID: 28556815; PMCID: PMC6152752.
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