Alleviating Pain & Managing Symptoms of Hemorrhoids & Anal Fissures with Compounded Medications

Many patients suffer from difficult-to-address gastrointestinal (GI) and rectal health conditions like hemorrhoids and anal fissures.

“Hemorrhoids are common in both men and women and affect about 1 in 20 Americans. About half of adults older than age 50 have hemorrhoids.”

Source: National Institute of Diabetes and Digestive and Kidney Diseases

Traditional medications that are mass-produced on the market don’t always provide the relief patients need, leading to a search for alternatives. 

This is where Health Dimensions Clinical Pharmacy (HDRx), a reputable compounding pharmacy, serving several states, plays a pivotal role by offering compounded medications tailored to meet the specific needs of patients struggling with these challenging conditions.

Understanding GI Challenges

Dealing with GI and rectal conditions can significantly impact your quality of life.

Anal fissures are small tears in the mucosa that lines the anus, which can cause severe pain and bleeding during and after bowel movements. Patients suffering from this condition often experience sharp, stabbing pain that can make everyday activities extremely uncomfortable. 

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The intense discomfort during bowel movements can also lead to fear of going to the bathroom, compounding constipation and exacerbating the problem. Many sufferers find that traditional over-the-counter and prescribed medications do not fully address their pain or facilitate healing, leaving them in a continual search for more effective solutions. This struggle for relief significantly impacts a patient’s quality of life, leading to frustration and distress over the ongoing pain and the challenge of managing symptoms effectively. HDRx understands that each patient’s experience with these conditions is unique, which is why we specialize in a personalized approach to addressing these symptoms.

“Anal fissure is a prevalent condition that affects a considerable number of individuals, with an estimated 342,000 new cases reported in the United States each year.”

Source: Life


Hemorrhoids are swollen veins in the lower rectum and anus, which can cause significant discomfort, itching, pain, and bleeding. This common condition can result from a variety of factors, including chronic constipation, pregnancy, and straining during bowel movements. Patients with hemorrhoids often struggle to find effective relief; over-the-counter creams and suppositories may offer temporary alleviation, but they rarely address the underlying inflammation or provide lasting comfort.

The pain and bleeding associated with hemorrhoids can make daily activities and basic needs like sitting and using the restroom challenging and uncomfortable. This ongoing discomfort often leads to a continuous search for more comprehensive and enduring methods and solutions, leaving patients feeling frustrated and hindered by their symptoms.

Targeted Delivery

Special GI specific formulations from HDRx come in many delivery forms, whether it’s an ointment, cream, gel, suppository, or oral medication. They are created by expert pharmacists to optimize absorption and target the affected area.

Compounded medications are commonly prescribed for:

    • Hemorrhoids
    • Anal fissures
    • Chronic diarrhea or constipation
    • Irritable Bowel Syndrome (IBS)
    • Inflammation of the GI tract



HDRx Gastroenterology Compound Spotlight

Learn more about commonly prescribed compounded medications at HDRx.

Diltiazem 2%/Lidocaine 3% Ointment

    • Used for anal fissures (tear near anus) 
    • Helps heal the fissure (wound) and relieve pain 
    • Application: dispensed with finger cots to make application less yucky 
    • Onset: pain relief should be quick. Healing will take longer, about 30 days or more.  

Hydrocortisone 25 mg/Lidocaine 10% Suppository

    • Used for hemorrhoids 
    • Helps shrink the hemorrhoids and relieve pain 
    • Application: suppositories require wetting with something, even water is helpful, but a personal lubricant is best (e.g., KY) 
    • Onset: quick relief from pain with lidocaine. Hemorrhoids take 2–3 weeks to resolve completely depending on the severity.

Other compounds:

    • Anti-inflammatory agents
    • Topical anesthetics for pain relief
    • Antispasmodics
    • Antibiotics or antifungals, when infections are present

For Practitioners: The Advantage of Prescribing Compounds for GI Patients

As a healthcare provider, you’re committed to offering your patients the best possible care. When standard methods and medications fall short, compounded medications from HDRx provide a versatile alternative. Custom compounding allows you to prescribe medications that are specific to each patient’s condition, symptom profile, history, and preferences.

Why Work with HDRx?

HDRx stands ready to support practitioners with expert advice on compounded options and quick turnaround times for prescriptions, with shipping available. Our commitment to quality and patient safety, underscored by our PCAB accreditation, ensures that you can prescribe with confidence.

Partner with HDRx for Compounded Solutions

Whether you’re a patient seeking relief from the painful symptoms of hemorrhoids and anal fissures or a practitioner looking for more options, HDRx is here to help. Our team of expert pharmacists takes pride in crafting custom compounded medications that offer a new level of targeted medications for GI and rectal conditions.

HDRx pharmacists are experts in Michigan, also serving nationally in states like OH, IN, IL, WI, and MN

With a focus on personalization, innovation, and quality, we’re not just filling prescriptions — we’re providing solutions. Let HDRx be your partner in achieving better health outcomes for GI and rectal conditions. Contact us to learn more about how our custom compounded medications can make a difference in the lives of your patients or in your own journey toward relief and recovery.


Bonaldi, Lorenza & Mascolini, Maria & Todesco, Martina & Zara, Anna & Rossato, Camilla & Fede, Caterina & Fontanella, chiara giulia & Stecco, Carla. (2023). Urinary Incontinence and Other Pelvic Floor Dysfunctions as Underestimated Problems in People under Forty Years: What Is Their Relationship with Sport?. Life. 14. 67. 10.3390/life14010067. 

Hemorrhoids. MedlinePlus website. NIH external link. Updated July 5, 2016. Accessed July 26, 2016.

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