Why is Compounded Metformin 30% Cream Commonly Prescribed for Melasma?

by | Jul 25, 2024 | Dermatology

At Health Dimensions Clinical Pharmacy (HDRx), our pharmacists are specially trained to compound medications for various dermatological conditions, including melasma. We ship prescription medications to multiple states: Michigan, Ohio, Indiana, Illinois, Wisconsin, Minnesota, and Florida.

Melasma, a common skin condition, presents as dark, discolored patches on the skin, primarily affecting the face. While traditional care plans have varied, recent studies, including one published in the Journal of Cosmetic Dermatology, suggest the use of topical metformin in addressing this condition.

The Challenge of Melasma

Melasma can significantly impact the quality of life due to its visible manifestations. Typically managed by a combination of sunscreen, makeup, and various depigmenting agents, the treatment of melasma often requires a multifaceted approach. The condition is particularly stubborn, often responding slowly to traditional treatments, which can be frustrating for patients seeking clear results.

Innovative Approach to Melasma with Compounded Metformin Cream

Recent clinical research has explored the use of metformin, traditionally known for its use in diabetes management, as a potential topical medication for melasma. 

“Metformin cream is a safe, [potentially] effective treatment for melasma.”

Source: Journal of Cosmetic Dermatology 

The study highlighted in the Journal of Cosmetic Dermatology demonstrated promising results in the preliminary clinical trial of topical metformin for melasma, providing a new hope for patients struggling with this condition.

What is the Research Saying?

Explore the various scientific studies that have been conducted in order to better understand the potential of utilizing metformin cream to address melasma.

Metformin Melasma: Woman's Face

Safety and efficacy of topical metformin 30% cream versus triple combination cream (Kligman’s formula) in treating melasma: A randomized controlled study

AboAlsoud ES, Eldahshan RM, AbouKhodair Mohammed H, Elsaie ML. Safety and efficacy of topical metformin 30% cream versus triple combination cream (Kligman’s formula) in treating melasma: A randomized controlled study. J Cosmet Dermatol. 2022 Jun;21(6):2508-2515. doi: 10.1111/jocd.14953. Epub 2022 Apr 9. PMID: 35357753.

Topical metformin in the treatment of melasma: A preliminary clinical trial

Banavase Channakeshavaiah R, Andanooru Chandrappa NK.J Cosmet Dermatol. 2020 May;19(5):1161-1164. doi: 10.1111/jocd.13145. Epub 2019 Sep 10.PMID: 31502392 Clinical Trial.

Study of oral tranexamic acid, topical tranexamic acid, and modified Kligman’s regimen in treatment of melasma.

Sahu PJ, Singh AL, Kulkarni S, Madke B, Saoji V, Jawade S.J Cosmet Dermatol. 2020 Jun;19(6):1456-1462. doi: 10.1111/jocd.13430. Epub 2020 Apr 28.PMID: 32346962 Clinical Trial.

A split-face comparison of fractional erbium: YAG laser plus Kligman’s formula vs. Kligman’s formula monotherapy for facial melasma

Nasimi M, Ghiasi M, Lajevardi V, Nasiri F, Shakoei S.Arch Dermatol Res. 2022 Oct;314(8):791-797. doi: 10.1007/s00403-021-02294-z. Epub 2021 Oct 27.PMID: 34705101 Clinical Trial.

A comprehensive review of the long-term and short-term treatment of melasma with a triple combination cream

Torok HM.Am J Clin Dermatol. 2006;7(4):223-30. doi: 10.2165/00128071-200607040-00003.PMID: 16901182 Review.

Why Choose HDRx for Prescription Metformin 30% Cream?

HDRx specializes in compounding metformin 30% cream, prescribed specifically for melasma. Our compounding pharmacists are experts in creating formulations that maximize the potential of the active ingredients for topical use.

  • Expert Formulation: At HDRx, our pharmacists utilize advanced compounding techniques to ensure each batch of metformin cream is precisely formulated for optimal skin absorption.
  • Customized Solutions: We understand that each case of melasma is unique. HDRx provides consultations to develop recommendations according to individual skin types and severity of discoloration, ensuring our patients receive a targeted approach.
  • PCAB Accredited: As a PCAB-accredited pharmacy, HDRx adheres to the highest standards of quality and safety in all our compounding processes. This accreditation assures that every product we dispense is of the utmost quality.
  • Broad Accessibility: Licensed to ship to multiple states, HDRx extends its expert compounding services beyond Michigan, providing access to patients and healthcare providers across multiple states looking for specialized melasma medications.
  • Supporting Research and Education: We believe in the power of education and informed decision-making. HDRx supports patients and healthcare providers by offering access to the latest research and information on medication advancements, including the use of compounded metformin cream for melasma.

Melasma medication requires innovative approaches, and the compounded metformin 30% cream offered by HDRx represents a significant advancement in addressing this challenging skin condition. By focusing on a compound that leverages dermatological research, HDRx demonstrates its commitment to pioneering patient care in the field of dermatology.

For those struggling with melasma, or healthcare providers seeking more options for their melasma patients, HDRx invites you to discover how our compounded metformin cream may make a difference. Contact our pharmacy to learn more about this innovative option prescribed for melasma and how it can be integrated into your or your patients’ care plans.

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